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Michael Rosemann Profile Page
Michael Rosemann
Research Area: Molecular Medicine
Research Topic: Cancer Research,Radiation Biology,Genetics,Susceptibility
Research Summary: The research of my group focusses on the role of adult stem cells for the live-long regeneration of organs and tissues and hence for the maintenance of health. We use in-vitro and in-vivo models of mesenchymal stem cells (MSC) to understand their potential for the prevention of age-related disorders such as cancer, osteoporosis but also diabetic wound healing problems. We investigate cellular pathways such as WNT/Dkk and CDKN2A/P16, which in MSCs are important regulators of ageing and stemness. For this, we use traditional knockout models, CrispR/CAS9 engineered mice and in-vitro knockdown systems.
We are also interested in the role of chronic, low-dose rate genotoxic stress on MSCs and the risk leading to malignant transformation. This is tightly linked with the problem of an individual, genetically determined susceptibility for sarcoma after radiation exposure. We have developed several mouse models that allow mapping of low-penetrance modifier genes and knock-out of candidate susceptibility genes. For radiation-induced osteosarcoma, we have now developed an in-vitro model of radiation-induced transformation, that gives us insight into the multistep mechanisms of malignant transformation in individual cells. We are currently also trying to exploit our murine tumor models as a tool for the development of novel cancer treatments.
Lab website:
Selected Publications: Bao X, Wang J, Zhou G, Aszodi A, Schönitzer V, Scherthan H, Atkinson MJ, Rosemann M. Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1-related genes and impairs DNA double-strand break recognition. FEBS Open Bio. 2020 Apr 25

Hladik D, Höfig I, Oestreicher U, Beckers J, Matjanovski M, Bao X, Scherthan H, Atkinson MJ, Rosemann M. Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability. Stem
Cell Res Ther. 2019 Jul 29;10(1):218.

Rosemann M, Gonzalez-Vasconcellos I, Domke T, Kuosaite V, Schneider R, Kremer M, Favor J, Nathrath M, Atkinson MJ. A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice. Mol
Cancer. 2014 Aug 4;13:182.

Gonzalez-Vasconcellos I, Anastasov N, Sanli-Bonazzi B, Klymenko O, Atkinson MJ, Rosemann M. Rb1 haploinsufficiency promotes telomere attrition and radiation-induced genomic instability. Cancer Res. 2013 Jul 15;73(14):4247-55.

Rümenapp C, Smida J, Gonzalez-Vasconcellos I, Baumhoer D, Malfoy B, Hadj-Hamou NS, Sanli-Bonazzi B, Nathrath M, Atkinson MJ, Rosemann M. Secondary
radiation-induced bone tumours demonstrate a high degree of genomic instability predictive of a poor prognosis. Curr Genomics. 2012 Sep;13(6):433-7.

Baumhoer D, Zillmer S, Unger K, Rosemann M, Atkinson MJ, Irmler M, Beckers J, Siggelkow H, von Luettichau I, Jundt G, Smida J, Nathrath M. MicroRNA profiling with correlation to gene expression revealed the oncogenic miR-17-92 cluster to be up-regulated in osteosarcoma. Cancer Genet. 2012 May;205(5):212-9.

Gonzalez-Vasconcellos I, Domke T, Kuosaite V, Esposito I, Sanli-Bonazzi B, Nathrath M, Atkinson MJ, Rosemann M. Differential effects of genes of the Rb1 signalling pathway on osteosarcoma incidence and latency in alpha-particle
irradiated mice. Radiat Environ Biophys. 2011 Mar;50(1):135-41.